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Proteomics is the study of proteins, which are the basic units of life that perform the functions of life. Compared to genomics, proteomics has a closer and more direct relationship with disease. This is because RNA expression levels are not highly correlated with protein expression levels, especially for low-abundance proteins. Additionally, 90% of drug targets and biomarkers used in clinical applications are proteins. Therefore, even though the development of nucleic acid levels has reached a fever pitch, the detection of proteomics is still very necessary.

IGEBio has launched the Olink targeted proteomics product, which can accurately detect body fluid samples, including low-abundance proteins.

Olink proteomics uses the proximity extension assay (PEA) technology, which combines the high specificity of antibody-based immunoassays and the high-throughput and high-sensitivity of genomics. It plays an important role in precision proteomics research and provides a new choice for multi-omics research. It has also been recommended by the Human Protein Atlas website as one of the three detection methods.

图1:THE HUMAN PROTEIN ATLAS/BLOOD PROTEIN

产品分类

96 Panel series：

14 human panels (7 major diseases, 7 biological pathways) + 1 mouse panel

384~3072 panel series：

Explore 384 Cardiometabolic

Explore 384 Neurology

Explore 384 Inflammation

Explore 384 Oncology

Olink Explore 1536

Olink Explore 3072

Researchers can choose the corresponding panel according to their research direction and disease type to complete targeted proteomics detection.

Experimental process

48/96panel series（qPCR）

Explore series（NGS）

PEA overcomes the technical challenges in proteomics

High specificity: Each target protein is recognized by two adjacent antibodies, and each protein is also labeled with a barcode.

High throughput: Rapidly detect 48-3072 target protein biomarkers in batch samples.

High sensitivity and wide detection range: The detection sensitivity can cover 10 logs, down to the fg/ml level, and cover proteins of different abundances, especially low-abundance inflammatory factors or cytokines.

More economical: A large number of target proteins can be equipped with the NGS platform to complete the detection economically and efficiently.

Low sample volume: Each sample requires only 1-6 ul, and 6 ul of sample can detect 3000 proteins.

Targeted: All detected proteins are biomarkers and cover 100% of signaling pathways (supported by top institutions and experts worldwide).

Multi-omics: It can be connected to NGS and qPCR platforms to produce data, and the flexible data model can be combined with multi-omics joint analysis.